Ethics and Practical Reason

In this review of essays on the topic of practical reason, the neo-Humeanism of philosophers such as James Drier, according to whom reasons are instrumental, is shown to be susceptible to the objections of Kantian philosophers such as Christine Korsgaard: the fact that you desire to X can never entail that you ought to X. Kantianism, however, comes under attack from neo-Aristotelian philosophers such as Berys Gaut, who argues that it is a mistake to identify goodness with being the object of free rational choice

Recovering Lost Moral Ground: Can Walt Make Amends?

Is it possible to recover lost moral ground? In the closing episodes of the TV show "Breaking Bad", it becomes clear that the protagonist, Walter White, believes that the correct answer to this question is an affirmative one. Walt believes that he can, and that he has, recovered lost moral ground. "Breaking Bad" may be said to explore two distinct and incompatible ways of attempting to recover lost moral ground. The first way is revisionist. This is to rewrite the script of what, morally speaking, has occurred, so that it appears that nothing wrong was done. The second way is restorative. This is to admit to morally wrongful behavior, but to attempt to make amends for it. While we concede that it is possible to recover lost moral ground in both of these ways, we deny that Walt is able to do so in both of these ways. At best, Walt can only hope to recover lost moral ground by attempting to make amends for his past misdeed

Innocent Burdens

In this article Judith Jarvis Thomson's Good Samaritan Argument in defense of abortion in the case of rape is defended from two objections: the Kill vs. Let Die Objection, and the Intend to Kill vs. Merely Foresee Death Objection. The article concludes that these defenses do not defend Thomson from further objections from Peter Singer and David Oderberg

Working with the Revenue code in 1956

https://egrove.olemiss.edu/aicpa_guides/2751/thumbnail.jp

Working with the Revenue code - 1958

https://egrove.olemiss.edu/aicpa_guides/2753/thumbnail.jp

Working with the Revenue code - 1957

https://egrove.olemiss.edu/aicpa_guides/2752/thumbnail.jp

Separating Autoimmune and Anti-Tumor Responses with HSP70iQ435A

Vitiligo and melanoma are both melanocyte-derived diseases; vitiligo progresses through the autoimmune-targeted destruction of healthy melanocytes while melanoma results from uncontrolled proliferation of cancerous melanocytes. Treatment of vitiligo with HSP70iQ435A inhibits the DC-mediated auto-immune response against melanocytes in vitiligo mouse models; this raises the concern that treatment with this modified HSP may also inhibit natural anti-tumor responses against melanocyte-derived melanoma tumor cells. We hypothesized that HSP70iQ435A prevents migration of melanocyte-antigen reactive T cells to the skin in a way that is mechanistically different from anti-tumor responses to melanoma and therefore would not have a negative effect on anti-tumor responses. We also hypothesized that treatment with HSP70iQ435A confers anti-melanoma resistance through antibody-dependent cell-mediated cytoxicity directed against surface-HSP70i on melanoma cells. Therefore, treatment with HSP70iQ435A may have therapeutic value in treatment of both vitiligo and melanoma